GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs726288 | 1 | rs4466773 | chr10:81733564 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs726288 | 1 | rs4466774 | chr10:81733786 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs9473555 | 1 | rs4469291 | chr6:49440614 | CENPQ | chr6:49431096-49460820:+ | -0.27 | -5.52 | 5.46E-8 | Folate pathway vitamin levels |
| THCA | cis | rs9473555 | 1 | rs4469291 | chr6:49440614 | MUT | chr6:49398994-49431031:- | 0.28 | 9.69 | 2.1E-20 | Folate pathway vitamin levels |
| THCA | cis | rs6479891 | 1 | rs4469774 | chr10:65309777 | LOC84989 | chr10:65224989-65226320:+ | 0.23 | 3.65 | 0.000286 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs4469774 | chr10:65309777 | NRBF2 | chr10:64893007-64914785:+ | 0.25 | 4.09 | 5.08E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs12216499 | 1 | rs4473887 | chr6:159369470 | RSPH3 | chr6:159398268-159421198:- | 0.28 | 6 | 3.97E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs7267979 | 1 | rs447722 | chr20:25443510 | ENTPD6 | chr20:25176339-25207360:+ | -0.31 | -6.86 | 2.13E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs447722 | chr20:25443510 | FAM182A | chr20:26035250-26067552:+ | -0.19 | -3.44 | 0.000643 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs447722 | chr20:25443510 | FAM182B | chr20:25744102-25848786:- | 0.26 | 5.33 | 1.52E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs447722 | chr20:25443510 | NINL | chr20:25433338-25566153:- | -0.35 | -7.19 | 2.46E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs447722 | chr20:25443510 | PYGB | chr20:25228706-25278647:+ | -0.15 | -3.67 | 0.000272 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs3796352 | 1 | rs4478072 | chr3:53106125 | RFT1 | chr3:53122503-53164470:- | 0.58 | 7.28 | 1.41E-12 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs7267979 | 1 | rs448396 | chr20:25440269 | ENTPD6 | chr20:25176339-25207360:+ | -0.31 | -6.86 | 2.13E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs448396 | chr20:25440269 | FAM182A | chr20:26035250-26067552:+ | -0.19 | -3.44 | 0.000643 | Liver enzyme levels (alkaline phosphatase) |